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In vivo chemical analysis and high-resolution imaging of atherosclerotic plaques using a near-IR fiber-optic catheter

Imaging algorithms for massively parallel supercomputers and intraarterial fiber-optic "cameras" are used in this project. The nondestructive chemical analysis of single lesions over time gives a new understanding of the mechanisms of lesion formation and growth. With other traditional techniques, vascular tissue must be removed before cholesterol and ox-LDL can be assayed. The advantage of the near-IR technique is that repeated analyses are possible of the same lesion during lesion formation and/or treatment. The technique will make possible tests of theories of lesion formation that are not possible with traditional techniques.

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