In vivo chemical analysis and high-resolution imaging of atherosclerotic plaques using a near-IR fiber-optic catheter
Imaging algorithms for massively
parallel supercomputers and intraarterial fiber-optic "cameras"
are used in this project. The nondestructive chemical analysis
of single lesions over time gives a new understanding of the mechanisms
of lesion formation and growth. With other traditional techniques,
vascular tissue must be removed before cholesterol and ox-LDL
can be assayed. The advantage of the near-IR technique is that
repeated analyses are possible of the same lesion during lesion
formation and/or treatment. The technique will make possible tests
of theories of lesion formation that are not possible with traditional
Return to the ASRG Home Page.