Multispectral Imaging of Intact Pharmaceutical
Imran Malik, Mela Poonacha, Jennifer Moses
Near-IR spectrometry and multivariate analysis has been used for analysis of intact tablets, and to discriminate between different tablet formulations inside blister packages. Current experiments test the hypothesis that visible / near-IR and IR imaging spectrometry permits the identity and composition of multiple individual tablets to be determined simultaneously through packaging. For example, near-IR cameras collect thousands of spectra simultaneously from a field of blister-packaged tablets. The BEST chemometric-imaging algorithm is used to draw probability-density contour plots that reveal tablet composition. The number of tablets that a typical near-IR camera can currently analyze simultaneously is approximately 1300.
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